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KMID : 0617320020110010314
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Journal of Pharmacetical Sceiences Ewha Womans University
2002 Volume.11 No. 1 p.314 ~ p.317
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Synthesis and Biological Evaluation of Novel d-2＇-Azido-2＇,3＇-dideoxyarabinofuranosyl-4＇-thiopyrimidines and Purines
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Kim, Hea Ok
Park, Yong Hee/Moon, Hyung Ryong/Jeong, Lak Shin
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Abstract
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Novel D-2´-azido-2´,3´-dideoxyarabonofuranosyl-4´-thiopyrimidines and purines have been synthesized, starting from L-xylose via azidation at the 2´-position as a key step. Most of the final nucleosides exhibited toxicity-dependent anti-HIV-l activity, among which D-α-adenine analogue 3h was found to be most cytotoxic.
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